L-asparaginase induced hyperlipidaemia in acute lymphoblastic leukaemia.

Cerebral Infarction in Childhood Acute Lymphoblastic Leukaemia Treated with Low Dose E. coli Asparaginase

Received September 16, 2005 Abstract The occurrence of thrombosis complicating L-asparaginase therapy in childhood acute lymphoblastic leukaemia has been supported by both laboratory and clinical evidences, but the exact pathogenic mechanism and predisposing factors remain elusive. Two children with acute lymphoblastic leukaemia (ALL) treated with chemotherapy developed cerebral infarction duri...

Myelosuppressive effect of colaspase (L-asparaginase) in initial treatment of acute lymphoblastic leukaemia.

Analysis of the remission induction phase in three Medical Research Council trials of treatment of acute lymphoblastic leukaemia has provided evidence of the adverse effect of the combination of colaspase (L-asparaginase) with vincristine and prednisolone. Significant myelosuppression, particularly of the granulocytic series, resulted in an increase in Gram-negative sepsis and death during the ...

Remission induction with cytosine arabinoside and L-asparaginase in acute lymphoblastic leukaemia.

Nine patients with acute lymphoblastic leukaemia in relapse were treated with a course of cytosine arabinoside followed immediately by a course of L-asparaginase. Eight patients achieved complete remission of their disease. This combination of drugs is sufficiently effective to suggest that further trial is needed. It is possible that the combination has a synergistic effect.

L-asparaginase in treatment of acute leukaemia and lymphosarcoma.

L-Asparaginase was used to treat 40 patients with acute leukaemia or lymphosarcoma. Fifteen with acute lymphoblastic leukaemia either untreated or in relapse after previous therapy were given "Squibb," "Bayer," or "Porton" L-asparaginase. Five of these patients had complete remission of their disease, and four had good partial remission. Eleven patients with acute myeloid leukaemia were treated...

Acute haemorrhagic pancreatitis following L-asparaginase therapy in acute lymphoblastic leukaemia --a case report.